The hard rock veterans were performing their opening song, Welcome to the Jungle, in Buenos Aires on the weekend when the frontman appeared visibly irritated.
In viral footage from the Saturday concert, Rose hurled his microphone toward the drum kit, kicked the kick drum, and stormed off stage.
All he said to the crowd was, "So, I'll just try and wing this."
The band have not addressed the incident, and it remains unclear whether he targeted the drum kit due to an issue with Carpenter.
Earlier in 2025, Guns N' Roses parted ways with longtime drummer Frank Ferrer, who was behind the kit for the band for almost two decades.
Carpenter - who is usually behind the kit for AWOLNATION - has been touring with them since.
Ferrer first joined the November Rain band during a show in June 2006, replacing Bryan Mantia. Ferrer's last show was in November 2023.
The band's lineup now consists of frontman Axl, Slash, Duff McKagan, Dizzy Reed, Richard Fortus, Melissa Reese, and Carpenter.
The official band statement said Ferrer made an "amicable exit", but he later admitted he was left feeling "disappointment" by the end of his tenure with the Sweet Child O' Mine rockers.
"The outpouring of love I have felt from the incredible fans of Guns N' Roses and my peers over the past 24 hours has been tremendous," Ferrer wrote on Instagram.
"I will have immense gratitude and love always for Axl and the band while at the same time, disappointment that this chapter came to an end."
Meanwhile, Slash recently promised a new record by the legendary group is "coming", but he cannot offer a time frame for when it will be released.
The group's last studio album was 2008's Chinese Democracy, but Slash and bassist Duff McKagan didn't feature on that record. Their last full-length project was 1993's The Spaghetti Incident?.
In 2023, the group released the tracks Perhaps and The General, which were both recorded around the same time as Chinese Democracy, just like 2021's Absurd and Hard Skool.