The Californian festival takes place across two weekends from Friday to Sunday and April 19 to 21 and will feature other headline performances from Tyler, The Creator, Doja Cat, and a No Doubt reunion with Gwen Stefani.
US singer Del Rey, who rose to fame in 2012 with Born To Die, will headline the Friday slot at the Empire Polo Club in Indio, California, having last appeared at the festival during her debut in 2014.
The Summertime Sadness star was scheduled to feature in the 2020 line-up, which was cancelled amid the COVID-19 pandemic.
The 38-year-old hit the headlines in 2023 after she arrived late for her performance at the BST Hyde Park festival in London, just weeks after her microphone was cut off at Glastonbury when her set over-ran because of her late arrival.
Coachella, renowned for attracting celebrities and influencers from across the world, will also feature Friday performances from Mexican singer Peso Pluma, South Korean DJ and singer Peggy Gou and US star Sabrina Carpenter, who opened for Taylor Swift at her recent Eras tour shows in Australia.
British musical stars descending on the desert include British DJ duo Anti Up and Gorgon City, MC and rapper Skepta, and indie pop star The Japanese House, real name Amber Bain.
Daisy Jones And The Six star Suki Waterhouse, who recently gave birth to her first child with Twilight actor Robert Pattinson, is also billed to perform at the festival on Friday.
The return of Coachella comes after the festival ran into problems with headline acts during the past two years.
Frank Ocean pulled out of his second headline performance in 2023 because of a leg injury while Kanye West, also known as Ye, was due to headline in 2022 until the line-up was updated weeks before the event.
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