Ash Riddell also had her sixth 40-plus disosals game - five of them this season - as the Kangaroos dominated from the start on Sunday at North Hobart Oval and won 9.13 (67) to 3.3 (21).
North will become the first AFL or AFLW team to win 24-straight games if they beat Hawthorn next Friday night, in the last round before the finals.
They equalled the mark set by Geelong through the 1952-53 VFL seasons.
But the win came at a cost, with Vicki Wall helped from the field in the last term suffering a left leg injury.
Saints mainstay Paige Trudgeon was also hurt in the final quarter.
Riddell, who set the AFLW record of 45 disposals earlier this month, ran amok again in the midfield and had 42 possessions.
Jas Garner also starred with 10 clearances and 30 possessions, while key forward Emma King kicked three first-half goals.
North have kicked at least 50 points in all 11 games this season and boast a whopping percentage of 317.9.
They have been unbeaten in 25 games since losing the 2023 grand final. The only blemish was last season's round-two draw with Geelong.
The loss ended St Kilda's six-game win streak and put a dent in their percentage as they try to make the finals for the first time.
They now must beat the Western Bulldogs at home next Sunday to stay in the top eight.
The Kangaroos rested key players Emma Kearney and Jenna Bruton, given the five-day break to the Hawthorn game, while Ella Slocombe made her senior debut.
Slocombe was prominent early as North kicked the first two goals and held the Saints to their first scoreless opening term of the season.
St Kilda upped their workrate in the second quarter and that led to Jesse Wardlaw kicking a goal midway through the term.
But North kicked four goals to two and the game was over at halftime with their lead at 38 points.
Serene Watson had a team-high 21 possessions for the Saints.
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