Andrews was on Sunday suspended over high contact that knocked out Bulldog Arty Jones, while star forward Zac Bailey and tall defender Darcy Gardiner received one-game bans for other incidents.
Brisbane are also awaiting the result of scans for co-captain and star midfielder Hugh McCluggage (calf).
Andrews and Jones had flown for an aerial contest and when the ball hit the deck, the Lions skipper flung back his left arm to block the Bulldog's run, but struck Jones in the face.
Jones was immediately treated and taken off with concussion.
The incident was assessed as careless conduct, high contact and severe impact, drawing a three-match suspension.
The loss of Andrews is massive given the Lions face red-hot Sydney and their new spearhead Charlie Curnow next week.
Andrews will also miss games against St Kilda and Collingwood.
Bailey was cited for a third-quarter elbow to the head of Bulldogs debutant Michael Sellwood after the Lions star was tackled over the boundary line by the defender.
It was considered intentional conduct, low impact and high contact.
Gardiner was cited for a high arm to Bulldogs forward Aaron Naughton, conceding a 50-metre penalty in the fourth term.
That incident was ruled high contact, medium impact and careless conduct.
Ruck recruit Sam Draper, who has battled foot soreness after recovering from an achilles tear, is a potential inclusion to face Sydney next Saturday.
Hard-nosed defender Noah Answerth also played a practice match in his successful return from the same injury.
Coach Chris Fagan will take comfort from the green on the statistics sheet after the two-time reigning AFL premiers' opening-round fumble.
The Lions had withstood the Bulldogs' best blows, kicking five consecutive majors to lead by 26 points late in the third term on Saturday.
But the Bulldogs surged back to win by five points - 16.15 (111) to 15.16 (106) - in an enthralling Gabba contest.
Fagan was left with plenty of positives despite the result.
"Not alarm bells," he said.
"You look at the stats and there's so much green here for us.
"That set of statistics is a good set against the Bulldogs.
"You take heart from that. They're a good team. Just a number of little things."
