On a night of utter chaos at Allianz Stadium, Mark Nawaqanitawase (ankle), Angus (knee) and Lindsay Collins (concussion) were all hurt as the Roosters shot out to a 30-0 lead.
Reece Walsh then exploded to life for Brisbane and got it back to 30-24 with 13 minutes to play, before a Patrick Carrigan error and Kotoni Staggs brain-snap killed off the comeback.
Nawaqanitawase's injury means his NSW State of Origin dream is over, with the Roosters expecting the winger to require surgery on a syndesmosis rupture.
There is hope Crichton's knee injury is not as serious, and he will be able to run out for the Blues in Origin I on May 28.
Nawaqanitawase's injury at least paved the way for Cody Ramsey to make an inspirational return to the NRL, after 1337 days out and a long battle with ulcerative colitis.
Brisbane's injury issues are worse, after entering Saturday night in sixth but with 10 players already sidelined.
Reynolds was left groggy after his head went into the turf trying to make a second-half tackle, meaning he will miss next week's clash with Manly.
Winger Jordan Karapani also suffered an ankle injury in a hip-drop tackle from Victor Radley, forcing him off the field and Deine Mariner back on after he too suffered a cork.
For 50 minutes on Saturday night the Roosters' attack was red hot, having now run in 205 points across a five-match winning streak.
James Tedesco threatened with every touch at No.1, with the former NSW captain's case for State of Origin recall growing stronger every week.
Reece Robson is also helping his own chances, with a good run out of dummy-half leading to the Roosters' first before darting over himself for their last.
Radley's return at lock has also added an extra bow to the Roosters' attack, digging into the line in the lead up to their second before Daniel Tupou joined Billy Slater on 190 career tries.
"We're very clear on how we want to attack, probably as clear as we've been in a couple of years," Roosters coach Trent Robinson said.
"It's the clarity and simplicity and then we're just working on the combinations as we go."
Naufahu Whyte and Nat Butcher were also immense up front, while Sam Walker set up one try with a grubber and scored one of his own when a Connor Watson kick rebounded off Ezra Mam.
But when Hugo Savala bombed a try and was denied by Walsh at 30-0 up early in the second half, the Tri-colours faltered.
Walsh then went over from dummy-half moments later, before stand-in halfback Tom Duffy put Xavier Willison into space.
Carrigan scored after Ramsey put down a Duffy bomb, and it was 30-24 with 13 minutes remaining when Walsh drew in two defenders and put Jordan Riki into a gap.
At that point the biggest comeback in premiership history loomed, only for a Carrigan error to kill off the next attacking raid.
And when Staggs was sin-binned for dropping his elbow into Savala's head after a tackle was complete, the comeback was over and he too now risks time on the sideline.
"That was my fault," Carrigan said.
"I made an error down in the good ball set, just loose carry turned over the ball and put us on the back foot and released pressure of the game.
"Kotoni plays aggressive, he wouldn't have meant to do any harm."
