Flanked by an ensemble of helpers in blood-stained hazmat suits, Klum was unrecognisable as she arrived for the New York party, with only her eyes and mouth showing.
The top of the hand ended in a gory assortment of dangling ligaments and tendons.
The idea came to her in 2025 to be a giant hand - specifically her own left hand, with long red nails, a thumb ring, and her engagement ring and wedding band.
"I looked at my hand and I thought, 'Hey, I think I could fit my body in this somehow'," Klum said.
The supermodel-turned-television personality went viral in 2022 when she arrived at the party on the end of a fishing line, encased in a slithering worm costume.
In past years, Klum has dressed as the Greek myth Medusa, a peacock, a 2.4-metre-tall Transformer, a werewolf from Michael Jackson's Thriller music video, a clone accompanied by several Klum-lookalikes, and Kali, the multi-armed Hindu goddess of death and destruction.
Klum said it took about five to six hours to get into her hand costume, but making it took much longer.
She posted hints on her Instagram earlier on Saturday as bloodied prosthetics were applied to her face.
"Hands down, the hardest thing is carrying it," Klum said.
"It's quite heavy."
Her husband, musician Tom Kaulitz, did not attend the party because he was on tour. But her costume included a tattoo of his name on her ring finger, along with her palm lines and veins.
"A little bit of Tom is with me," she said.
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