The UK's Crown Prosecution Service said the new charges — one count of rape and one of sexual assault — against Brand were in relation to two further women.
The alleged offences took place in 2009, the service said.
Brand, 50, had already been charged in April with two counts of rape, two counts of sexual assault and one count of indecent assault.
The charges were brought following an 18-month investigation sparked when four women alleged they had been assaulted by the controversial comedian.
Prosecutors said these offences took place between 1999 and 2005 — one in the English seaside town of Bournemouth and the other three in London.
Brand pleaded not guilty to those charges in a London court earlier in 2025.
He is expected to appear next in court on January 20, in relation to the two new charges.
A trial has also been scheduled for June and is expected to last four to five weeks.
The Get Him To The Greek actor, known for risqué stand-up routines, battles with drugs and alcohol, has dropped out of the mainstream media in recent years.
He built a large following online with videos mixing wellness and conspiracy theories, as well as discussing religion.
When the first batch of charges was announced in April, Brand said he welcomed the opportunity to prove his innocence.
"I was a fool before I lived in the light of the Lord," he said in a social media video.
"I was a drug addict, a sex addict and an imbecile. But what I never was a rapist. I've never engaged in non-consensual activity. I pray that you can see that by looking in my eyes."
The Associated Press doesn't name victims of alleged sexual violence, and British law protects their identity from the media for life.
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