"At this time we can confirm that three people are dead, two adults and one child as a result of the tornado that touched down this afternoon," the Montgomery County in Tennessee said on its Facebook page.
Additionally, 23 people have been treated at the hospital.
Three more deaths were reported in the suburbs of Nashville, the Nashville Office of Emergency Management said on X, formerly called Twitter.
More than 80,000 people in Tennessee were left without power as of Saturday evening, according to outage tracking website poweroutage.us.
"This is a day that nobody wanted or expected," a Tennessee mayor said. (AP PHOTO)
"This is a sad day for our community. We are praying for those who are injured, lost loved ones, and lost their homes," Montgomery County mayor Wes Golden said.
The Montgomery County Sheriff's Office said there was damage to several homes in the city of Clarksville.
Multiple trees, power lines and houses were also hit by storms in the rural town of Dresden, emergency services said.
Montgomery County, where Clarksville is located, has a population of more than 220,000.
Officials also urged people to stay off the roads as emergency services were responding to the situation in different areas.
"We are still in the search and rescue phase of this disaster," the Montgomery County said in its Facebook statement.
A school and church were set up to shelter those displaced or in need of assistance.
The National Weather Service had issued a tornado emergency alert earlier on Saturday afternoon for several Nashville suburbs.
"This is a day that nobody wanted or expected," Clarksville mayor Joe Pitts said.
"We know there's extensive damage throughout the community."
