Dayne Zorko, Darcy Gardiner and Daniel Annable will face Hawthorn at the Gabba on Friday, six days after being demolished by the Blues.
Keidean Coleman misses with concussion, Hugh McCluggage will sit out with a calf injury, while Bruce Reville has been dropped.
Defender Ryan Lester (shoulder) and Logan Morris (soreness) have overcome injury concerns to take their place in the blockbuster match that will shape the top-four.
For the Hawks, Karl Amon, Mitch Lewis, Sam Butler and Ned Reeves are all back in a massive boost as they aim to win at the Gabba for the first time since 2016.
On Saturday, ladder-leaders Fremantle will be missing captain Alex Pearce, who will be managed for the clash with Melbourne at the MCG.
Fellow defender Brennan Cox takes Pearce's spot as the Dockers look to gain valuable experience in Melbourne ahead of a possible return in grand-final week.
The Demons have regained key defender Daniel Turner and crafty forward Kade Chandler, while Latrelle Pickett will miss again due to concussion.
Collingwood will be without Jordan De Goey and Scott Pendlebury for Sunday's crucial match against West Coast.
They join injured trio Harry Perryman, Pat Lipinski and Jeremy Howe on the sidelines.
Geelong captain Patrick Dangerfield will miss a second-straight game due to a hip problem, while Sam De Koning has been recalled to give young ruck Mitch Edwards a rest.
The Cats will host Essendon at GMHBA Stadium on Saturday.
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