"The Great, and even Legendary, Charlie Kirk, is dead. No one understood or had the Heart of the Youth in the United States of America better than Charlie. He was loved and admired by ALL, especially me, and now, he is no longer with us," Trump wrote on social media.
A university spokesperson said police did not have a suspect in custody. Earlier, the school had reported that someone had been detained.
Mobile phone video clips of the incident circulating on social media showed Kirk addressing a large outdoor crowd at the Utah Valley University campus in Orem, Utah, when a loud crack that sounded like a gunshot rang out. Kirk moved his hand toward his neck as he fell off his chair, sending the attendees running.
In another clip, blood can be seen gushing from Kirk's neck immediately after the shot. Reuters has not confirmed the authenticity of the videos.
Kirk and the group he co-founded, Turning Point USA, the largest conservative youth organisation in the country, played a key role in driving young voter support for Trump in November.
Kirk's appearance on Wednesday was the first in a planned 15-event "American Comeback Tour" at universities around the country. He often used such events, typically drawing large crowds of students, to invite attendees to debate him live. Before he was shot, Kirk was sitting at what he calls a "Prove Me Wrong" table to field questions from the audience.
Kirk had 5.3 million followers on X and hosted a popular podcast and radio program, "The Charlie Kirk Show." He had also recently co-hosted "Fox & Friends" on Fox News.
He was part of an ecosystem of pro-Trump conservative influencers – including Jack Posobiec, Laura Loomer, Candace Owens and others – who have helped to amplify the president's agenda. Kirk frequently attacked mainstream media and engaged in culture war issues around race, gender and immigration, often in a provocative style.
Both Republican and Democratic politicians expressed support for Kirk following the shooting.
"Eternal rest grant unto him, O Lord," Vice President JD Vance, who was close to Kirk, wrote on X.
"The attack on Charlie Kirk is disgusting, vile, and reprehensible," Democratic California Governor Gavin Newsom said on X. "In the United States of America, we must reject political violence in EVERY form."
with AP